Product Details:
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Trade Term: | FOB,CIF, EXW | Product Name: | Estradiol |
---|---|---|---|
Appearance: | White Crystalline Powder | Export Markets: | Global |
Standard: | USP | Purity: | 99% |
Policy: | Re-Shipping Policy | Supply: | In Stock |
High Light: | raw hormone powder,bodybuilding supplements steroids |
White Estradiol Raw Steroid Powders Infrared Absorption High Pure
Product Details:
1, Manufacturer :Holy Biological
2, MF:C18H24O2
3, MW:272.38
4, Purity:99%
5, Character: White Crystalline Powder
6, Stability: Stable. Incompatible with strong oxidizing agents.
Description:
Estradiol, or more precisely, 17β estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.
Estradiol or oestradiol (American or British English usages), derives from estra Gk. οἶστρος (oistros, literally meaning "verve or inspiration [4] and diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups.
Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone producing) and non endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone).[citation needed] One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.[citation needed] Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.[citation needed]
Effects :
Female reproduction: In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production. In baboons, blocking of estrogen production leads to pregnancy loss, suggesting estradiol has a role in the maintenance of pregnancy. Research is investigating the role of estrogens in the process of initiation of labor. Actions of estradiol are required before the exposure of progesterone in the luteal phase.
Sexual development: The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol enhances breast development, and is responsible for changes in the body shape, affecting bones, joints and fat deposition. Fat structure and skin composition are modified by estradiol.
Male reproduction: The effect of estradiol (and estrogens) upon male reproduction is complex. Estradiol is produced by action of aromatase mainly in the Leydig cells of the mammalian testis, but also by some germ cells and the Sertoli cells of immature mammals. It functions (in vitro) to prevent apoptosis of male sperm cells.
Several studies have noted sperm counts have been declining in many parts of the world, and estrogen exposure in the environment has been postulated to be the cause.
Suppression of estradiol production in a subpopulation of subfertile men may improve the semen analysis.
Males with sex chromosome genetic conditions, such as Klinefelters syndrome, will have a higher level of estradiol.
Bone[edit]Estradiol has a profound effect on bone. Individuals without it (or other estrogens) will become tall and eunuchoid, as epiphyseal closure is delayed or may not take place. Bone structure is affected also, resulting in early osteopenia and osteoporosis. Also, women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency.
Liver: Estradiol has complex effects on the liver. It can lead to cholestasis. It affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood clotting.
Brain: Estrogens can be produced in the brain from steroid precursors. As antioxidants, they have been found to have neuroprotective function.
Specifications :
Estradiol |
Batch Size |
Quantity |
1kg |
Manufacturing Date |
2015.05.08 |
Batch No. |
20150508 |
Expiry Date |
2017.07.07 |
Report Date |
2015.05.17 |
Reference Standard |
USP 34 |
Packing |
Foil bag |
TEST |
ACCEPTANCE CRITERIONS |
RESULTS |
|
Identification |
Infrared Absorption |
Positive |
|
Characteristics |
White or creamy white, crystalline powder |
conform |
|
Melting point |
173 ~ 179degree |
177~ 179degree |
|
Specific rotation |
76°~83° |
78.5° |
|
Water |
≤3.5% |
pass |
|
Assay |
97 .0~ 103.0percent |
99.37% |
|
Loss on drying |
≤0.5percent |
0.21% |
|
Related substances |
total impurities ≤1.0percent |
Pass |
|
Residual solvents |
ethanol ≤0.5percent |
Pass |
|
Conclusion |
This batch complies with USP 34 |
Competitive Advantage:
1. We are a professional manufacturer of raw steroid powders from China. Our company has been specialized in this field for many years and won great reputation in all of our customers.
2. our products have exported to US, Brazil, Canada, Germany, UK, Spain, France, Norway, Romania, Italy, Australia and many other areas. We build long-term cooperation relationship with all of the customers.
3. Could be shipped out within 24 hours after received the payment.
4. High quality, best price, first-class service, high successful delivery rate.
Contact Person: Mr. Jackson